A New, Highly Mutated COVID Variant Called ‘Cicada’ Is Spreading in the US

COVID ‘Cicada’ Variant Spreading in the US: Symptoms, Risks & Expert Guidance | Omisha Healthcare
Breaking Health Alert

A New, Highly Mutated COVID Variant Called ‘Cicada’ Is Spreading in the US

BA.3.2, nicknamed Cicada, carries 70 to 75 spike protein mutations and has been detected in 25 states. Here is everything American families need to know — symptoms, risks, and expert guidance.

Updated: March 27, 2026 Reviewed by Medical Experts 12 min read CDC Sourced
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The COVID Variant That Emerged From the Shadows

Just when most Americans assumed COVID-19 had retreated to background noise, a new variant is drawing serious attention from public health officials. BA.3.2 — nicknamed “Cicada” by the scientific community — is a heavily mutated strain of SARS-CoV-2 that has been quietly spreading across the United States, now confirmed in at least 25 states by the U.S. Centers for Disease Control and Prevention (CDC).

The name is apt. Like the insects that lie dormant underground for years before emerging en masse, this variant simmered largely undetected after its first appearance, then began accelerating in fall 2025. Now, health experts are watching it closely — not because it appears more deadly, but because of something arguably more complex: its extraordinary ability to potentially sidestep your immune defenses.

Health Alert: CDC is Actively Monitoring BA.3.2

As of March 2026, BA.3.2 (Cicada) has been detected in wastewater samples from at least 132 sites across 25 US states. The WHO classified it as a “variant under monitoring” in December 2025. Current overall risk to the general public remains low, but surveillance is ongoing.

25+
US States With Detected Cases
70-75
Spike Protein Mutations vs. Prior Variants
23+
Countries Reporting BA.3.2 Cases Globally
Origin & Discovery

From South Africa to San Francisco: The Cicada Timeline

Tracing the origin of BA.3.2 reveals an unusual trajectory — one that distinguishes it from recent dominant variants. While strains like XFG (Stratus) and NB.1.8.1 (Nimbus) descend from the JN.1 lineage, Cicada belongs to a completely different lineage. The CDC describes BA.3.2 as “genetically distinct” from the family of variants that has dominated the past two years.

November 2024
First global detection of BA.3.2 in South Africa. The variant begins a slow, quiet existence — almost entirely underground.
June 2025
First US detection: a traveler returning from the Netherlands is screened at San Francisco International Airport, per the CDC. The variant is noted but not yet spreading domestically.
September 2025
BA.3.2 begins accelerating in multiple countries. Virologists at Johns Hopkins and other institutions flag its unusual mutation profile for closer study.
December 2025
The World Health Organization officially classifies BA.3.2 as a “variant under monitoring,” acknowledging its potential for immune escape.
January 2026
First confirmed US patient case (not a traveler) is diagnosed. BA.3.2 has officially moved from imported detection to domestic spread.

The nickname “Cicada” was coined by T. Ryan Gregory, Ph.D., a professor of evolutionary biology at the University of Guelph, Canada — the same researcher who has named other variants including “Stratus” and “Pirola.” The name perfectly encapsulates the variant’s behavior: a long dormancy period followed by a sudden, widespread emergence.

“It was under the radar, replicating, until it started to spread more from person to person. BA.3.2 has a lot of mutations that may cause it to look different to your immune system.”

AP
Andrew Pekosz, Ph.D.
Virologist, Johns Hopkins Bloomberg School of Public Health
The Science of Cicada

What Makes BA.3.2 Different From Every Other Variant?

COVID variants come and go, and most make only incremental changes to the virus’s structure. Cicada is different in a way that demands scientific attention: it carries 70 to 75 mutations in its spike protein — the part of the virus that attaches to human cells and that vaccines are designed to target. That number is extraordinarily high.

Understanding Spike Protein Mutations

The spike protein is the key the virus uses to enter human cells. It is also the primary target of COVID-19 vaccines and the part of the virus your immune system learns to recognize after infection. When the spike protein mutates significantly — as it has in BA.3.2 — your immune antibodies may not recognize the new version as efficiently, potentially reducing protection against infection (though not necessarily against severe disease).

The 2025-2026 COVID vaccine was formulated to target the JN.1 lineage — the backbone of most recent dominant variants. Since Cicada diverges dramatically from JN.1, early laboratory studies suggest the current vaccine may offer reduced protection against BA.3.2 infection. However — and this is critical — experts emphasize that vaccines still appear to protect against severe illness and hospitalization. The goal of COVID vaccination has always been to prevent the worst outcomes, not to eliminate infection entirely.

Important Context: Vaccine Effectiveness

Lab studies show reduced antibody neutralization of BA.3.2 from current vaccines. However, the CDC and infectious disease experts confirm that existing vaccines are still expected to protect against severe illness, hospitalization, and death — even from this variant. Getting vaccinated and boosted remains the most important protective step Americans can take.

There is an interesting biological nuance that offers some reassurance. According to Dr. Pekosz and colleagues, some of Cicada’s mutations may actually make the virus bind less effectively to human cells. This could mean that while the variant evades immune recognition, it may also be less efficient at establishing infection — a biological trade-off that scientists are continuing to study.

Symptoms

COVID ‘Cicada’ Symptoms: What to Watch For in 2026

Here is the reassuring news on symptoms: according to the CDC and infectious disease physicians who have treated early BA.3.2 cases, the symptom profile of Cicada is consistent with other COVID-19 variants currently in circulation. There is no evidence that Cicada causes a unique constellation of symptoms, nor that it produces significantly worse illness in the general population.

That said, one symptom has been highlighted by clinicians as notably prominent in recent COVID infections: a severe sore throat, sometimes described as a “razorblade throat” sensation. Dr. Robert H. Hopkins Jr., Medical Director of the National Foundation for Infectious Diseases, specifically cited this as a common report alongside standard COVID symptoms.

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Fever or Chills
A sudden onset of fever is one of the classic early warning signs. May be accompanied by chills or night sweats.
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Cough
A persistent, dry or productive cough remains a hallmark COVID symptom across all known variants.
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Shortness of Breath
Difficulty breathing or feeling winded with minimal exertion warrants immediate medical evaluation.
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Severe Sore Throat
Clinicians are noting “razorblade throat” pain as a notable symptom. More intense than a typical sore throat.
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Congestion or Runny Nose
Upper respiratory symptoms are common. May appear similar to a cold or seasonal allergy at first.
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Fatigue
Extreme tiredness that feels out of proportion to activity level. Can persist even after other symptoms resolve.
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Headache
Moderate to severe headaches, sometimes accompanied by light sensitivity, have been reported in COVID cases.
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Muscle or Body Aches
Myalgia (muscle pain) is common and can be widespread. Often described as feeling like the flu.
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Loss of Taste or Smell
While less prominent than in early pandemic variants, anosmia and ageusia can still occur with newer strains.
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Nausea, Vomiting, or Diarrhea
Gastrointestinal symptoms affect a portion of COVID patients and can be the primary or only presenting symptom.
When to Seek Emergency Care

Call 911 or go to the nearest emergency room if you experience: trouble breathing, persistent chest pain or pressure, confusion or altered mental status, inability to stay awake, or bluish discoloration of lips or fingernails. These are signs of severe COVID-19 requiring immediate attention.

Spread Across America

Where Has Cicada Been Detected in the United States?

The CDC’s primary method for tracking BA.3.2 is wastewater surveillance — an approach that has proven far more sensitive than clinical testing alone, particularly as at-home testing has become more common and many mild cases go unreported. As of February 11, 2026, wastewater samples containing genetic signatures of BA.3.2 have been collected from 132 sites spanning at least 25 states.

States Where BA.3.2 Has Been Detected (Per CDC Wastewater Data)
California Connecticut Florida Hawaii Idaho Illinois Louisiana Maine Maryland Massachusetts Michigan Missouri New Hampshire New Jersey Nevada New York Ohio Pennsylvania Rhode Island South Carolina Texas Utah Vermont Virginia Wyoming

It is important to put these detections in perspective. As of late March 2026, BA.3.2 represents approximately 0.55% of sequenced COVID cases in the United States — still a tiny fraction compared to the dominant variants XFG (Stratus) and NB.1.8.1 (Nimbus). However, the direction of the trend is what concerns epidemiologists: wastewater data from WastewaterSCAN, the Stanford University-led tracking program, found BA.3.2 in 11% of national samples during the week ending March 21, 2026 — a meaningful increase from 3.7% earlier in the month.

The European Warning Signal

European data provides a cautionary preview. BA.3.2 already accounts for approximately 30% of COVID-19 sequences in Germany, Denmark, and the Netherlands — nations that saw their own slow rise before a significant jump. This trajectory from low prevalence to dominant strain in Europe has placed US public health officials on alert. Whether the same progression will occur in America remains unknown, but the pattern is being watched carefully.

Severity Assessment

Is Cicada More Dangerous? What Experts Actually Say

The question every American rightly wants answered is: will this variant make people sicker? Based on all available evidence as of late March 2026, the answer is: not significantly so, compared to current circulating variants. Every known case of BA.3.2 in the United States has been relatively mild, and there has been no documented spike in deaths or hospitalizations linked specifically to this variant.

“I have not seen any data which indicates that Cicada is any more severe than other circulating variants. Severe sore throat is reported as a common symptom along with other typical COVID symptoms.”

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Dr. Robert H. Hopkins Jr.
Medical Director, National Foundation for Infectious Diseases

It is crucial, however, to place this reassurance in the right context. COVID-19 continues to kill approximately 100,000 Americans annually, with older adults, immunocompromised individuals, and those with underlying health conditions carrying the greatest burden of serious illness. Even a variant that is not inherently more severe can cause significant harm if it reinfects large numbers of people who previously had partial immunity.

Factor BA.3.2 (Cicada) Current Assessment
Severity vs. other variants Comparable — no increase documented Low added concern
Immune escape potential High — 70-75 spike mutations Moderate-high concern
Current vaccine effectiveness Reduced for infection; likely maintained for severe disease Moderate concern
Antiviral drug sensitivity Sensitive — existing antivirals appear effective Reassuring
Dominant in US? No — approx. 0.55% of cases as of early 2026 Low current prevalence
Growth trend in wastewater Rising — from 3.7% to 11% in weeks Under active monitoring

One notable piece of good news: according to Adolfo Garcia-Sastre, Ph.D., a virologist at the Icahn School of Medicine at Mount Sinai, “The new variant is still sensitive to COVID antiviral drugs that we have been developing, so at least those will work.” Antivirals like Paxlovid and Lagevrio remain effective treatment options for eligible patients, particularly those at high risk of severe disease.

Who Is Most at Risk?

Who Should Be Most Vigilant About Cicada?

While the general public faces a currently low risk from BA.3.2, certain groups in the United States face meaningfully higher risk of serious outcomes from any COVID-19 infection. Public health officials and physicians urge these populations to take heightened precautions.

High-Risk Groups: Extra Caution Warranted
  • !Adults 65 and older — Age remains the single strongest predictor of severe COVID outcomes.
  • !Immunocompromised individuals — Including those on immunosuppressive medications, organ transplant recipients, and people with certain cancers.
  • !Those with chronic conditions — Including heart disease, diabetes, chronic lung disease, kidney disease, and obesity.
  • !Unvaccinated individuals — Particularly vulnerable to severe illness and at higher risk from immune-escaping variants.
  • !Pregnant individuals — COVID infection during pregnancy is associated with increased risk of complications for both mother and baby.

Dr. Hopkins delivered a sobering public health assessment: “Low vaccination rates and little to no public health effort toward stopping COVID infections and spread leaves us vulnerable.” This statement underscores a broader concern: the reduction of public health infrastructure and surveillance capacity since the official end of the COVID emergency may limit the US ability to respond rapidly if BA.3.2 gains significant traction.

Protection Guide

What the CDC Recommends to Protect Yourself From Cicada

The fundamentals of COVID protection have not changed, even as the virus continues to evolve. The CDC and leading infectious disease physicians align on the following practical steps for all Americans — and especially for those in high-risk categories.

Get Vaccinated and Stay Current

The 2025-2026 COVID vaccine is still your best protection against severe illness, even from novel variants. If you have not received your latest booster, speak with your healthcare provider. Vaccine formulations may be updated if BA.3.2 becomes more dominant.

Improve Indoor Ventilation

SARS-CoV-2 spreads primarily through respiratory aerosols. Opening windows, using air purifiers with HEPA filters, and ensuring good airflow in enclosed spaces significantly reduces transmission risk.

Wear a Quality Mask in Crowded Spaces

An N95 or KN95 respirator provides the best protection in high-risk settings like crowded public transportation, medical facilities, or large indoor events — especially if you or someone in your household is high-risk.

Test When Symptomatic

Rapid antigen tests remain available for home use. Testing when you develop symptoms — even mild ones — helps confirm COVID infection and allows timely access to antiviral treatments, which must be started early to be effective.

Practice Good Hand Hygiene

Wash hands frequently with soap for at least 20 seconds, especially before touching your face, after being in public spaces, and after coughing or sneezing. Use alcohol-based hand sanitizer when soap is unavailable.

Stay Home When Sick

If you develop COVID symptoms, isolate at home and avoid contact with others — especially those who are elderly or immunocompromised. Contact your healthcare provider about antiviral treatment eligibility, particularly if you are high-risk.

About COVID Antivirals: Act Fast

If you test positive for COVID-19 and are at high risk for severe illness, contact your doctor immediately about antiviral medications. Antivirals like Paxlovid (nirmatrelvir-ritonavir) are most effective when started within 5 days of symptom onset. Do not wait to see if symptoms worsen before seeking treatment. Since BA.3.2 is still sensitive to existing antivirals, eligible patients can benefit from these treatments.

The Bigger Picture

Will Cicada Become the Dominant Strain? What Comes Next?

The honest scientific answer is: we do not yet know. COVID-19 has repeatedly surprised even the world’s best epidemiologists. What can be said with confidence is that BA.3.2 has not yet shown the explosive global growth advantage that would mark it as clearly dominant. The WHO noted in early 2026 that despite its many mutations, BA.3.2 had not demonstrated “a sustained growth advantage over any other co-circulating variant.”

Even if Cicada can partially evade existing immunity, our immune systems are not starting from zero. Years of vaccination and prior infections have built layered immune responses that extend beyond antibody recognition alone. There will likely be some “cross-reactivity” — meaning our immune systems will still recognize some aspects of BA.3.2, even if the response is less robust than against known strains.

“If it had really special advantages, we’d probably have seen it take off and dominate globally relatively quickly. We didn’t see that, but it’s not going away, so it’s something to keep an eye on. It may evolve to be a bit better at spreading or causing disease, but we just don’t know.”

AP
Andrew Pekosz, Ph.D.
Virologist, Johns Hopkins Bloomberg School of Public Health

One concern raised by experts is the significant reduction in COVID surveillance infrastructure in the US. With fewer clinical tests being processed and reported, and reduced federal public health capacity, the country may be slower to detect a meaningful surge in BA.3.2 infections. Wastewater surveillance — the primary tool currently tracking this variant — provides directional signals but cannot capture the full clinical picture alone.

The Surveillance Gap: A Hidden Risk

“There are still a lot of unknown questions about how prevalent it is in the US, because surveillance has been reduced a lot,” said Dr. Garcia-Sastre. This gap between actual infections and reported cases means that BA.3.2 may be more widespread than current data reflects. Continued investment in wastewater monitoring and genomic sequencing programs is essential for early warning of any new wave.

Omisha Healthcare Guidance

What Omisha Healthcare Advises for American Families

At Omisha Healthcare, our mission is to provide you with evidence-based health information that empowers real decisions — not panic, and not complacency. Here is our consolidated guidance based on the current state of BA.3.2 in the United States:

  • ✓Do not panic. Current US prevalence of BA.3.2 remains low. The overall risk to healthy adults is low at this time. Monitor credible sources like the CDC website for updates.
  • ✓Do stay informed. Check CDC wastewater data and your state health department for local updates on BA.3.2 prevalence in your area.
  • ✓Do get vaccinated if you have not. The current vaccine still protects against severe disease. Talk to your doctor or pharmacist about whether a booster is recommended for you.
  • ✓Do take symptoms seriously. If you develop COVID-like symptoms — especially that notable severe sore throat — test promptly. If high-risk, contact your provider about antivirals immediately.
  • ✓Do protect vulnerable loved ones. If you live with or regularly see elderly family members, immunocompromised individuals, or others at high risk, take extra care — mask in crowded spaces, avoid them if you are symptomatic.
  • ✗Do not dismiss it as “just a cold.” COVID continues to claim lives and cause Long COVID complications in a meaningful fraction of patients. Treat it with appropriate respect.
  • ✗Do not assume past infection equals full protection. Cicada’s immune evasion profile means prior infection or vaccination may not fully protect against reinfection. Maintained precautions are wise, especially indoors with poor ventilation.
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Omisha Healthcare Editorial Team
Medical Content Division | omishahealthcare.com

The Omisha Healthcare Editorial Team consists of US-based healthcare professionals, medical writers, and public health researchers dedicated to delivering accurate, timely, and actionable health information. Our content is reviewed against CDC guidelines, peer-reviewed research, and expert clinical practice. We adhere to strict E-E-A-T standards — experience, expertise, authoritativeness, and trustworthiness — in every article we publish. Content is updated as new information becomes available.

Sources & References
[1]U.S. Centers for Disease Control and Prevention (CDC) — BA.3.2 Variant Tracking, Morbidity and Mortality Weekly Report, March 2026
[2]World Health Organization (WHO) — Variants Under Monitoring Classification, December 2025
[3]Andrew Pekosz, Ph.D. — Johns Hopkins Bloomberg School of Public Health, Virology Research
[4]Dr. Robert H. Hopkins Jr. — National Foundation for Infectious Diseases, Medical Director Statement
[5]WastewaterSCAN — Stanford University Disease Surveillance Program, March 2026 Data
[6]T. Ryan Gregory, Ph.D. — University of Guelph, Evolutionary Biology; Variant Naming Research
[7]Global Initiative on Sharing All Influenza Data (GISAID) — BA.3.2 International Genomic Database
[8]Adolfo Garcia-Sastre, Ph.D. — Icahn School of Medicine at Mount Sinai, Virological Assessment
[9]NBC News / TODAY.com — BA.3.2 Coverage and Expert Interviews, March 27, 2026
[10]USA Today / Detroit News — BA.3.2 State-Level Spread Reporting, March 2026
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you may have regarding a medical condition. In a medical emergency, call 911 immediately. The information presented in this article is based on publicly available data from the CDC, WHO, and academic research institutions as of March 27, 2026, and may be updated as new information becomes available. Omisha Healthcare is committed to editorial independence and does not accept sponsorship that influences health content.

Copyright 2026 Omisha Healthcare  |  omishahealthcare.com  |  All Rights Reserved

This content is for informational purposes only. Not a substitute for professional medical advice.

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Omisha is a health writer passionate about turning complex medical research into clear, actionable content readers can trust. She covers everything from nutrition and mental wellness to chronic disease management, always grounding her work in credible science and real-world relevance. When she's not writing, she's usually reading up on the latest health studies or exploring new wellness trends to write about next.

Omisha

Omisha

Omisha is a health writer passionate about turning complex medical research into clear, actionable content readers can trust. She covers everything from nutrition and mental wellness to chronic disease management, always grounding her work in credible science and real-world relevance. When she's not writing, she's usually reading up on the latest health studies or exploring new wellness trends to write about next.

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